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Minoxidil 5%, Tretinoin 0.05%, Melatonin 1% and 17-alpha Estradiol 0.05% Topical Scalp Serum (Alcohol Free)
The active ingredients in this formulation include Minoxidil 5%, Tretinoin 0.05%, Melatonin 1% and 17-alpha Estradiol 0.05%. Minoxidil is a potent vasodilator utilised in the treatment of hair loss and pattern baldness. It functions by enhancing blood circulation to the scalp, thereby stimulating hair growth. Tretinoin, a retinoid, enhances the penetration of minoxidil and may improve the health and function of the hair follicle. Melatonin is included for its anti-inflammatory, DHT blocking and antioxidant effects, which can help repair and rejuvenate the skin. 17-alpha Estradiol inhibits the conversion of testosterone to the metabolite dihydrotestosterone (DHT) by suppressing 5AR activity. In addition, by inhibiting dehydrogenase, it reduces the conversion process of androstenedione to testosterone, resulting in a reduction in the synthesis of testosterone and DHT.
Personalised Hair Growth Treatments
Ongoing Clinical Guidance and Support
Medical Consultation Required
Formula Information
GrowBack’s Minoxidil 5%, Tretinoin 0.05%, Melatonin 1% and 17-alpha Estradiol 0.05% Scalp Serum is a specially compounded liquid formulation designed for topical application to the scalp. This unique blend of active ingredients is dispensed in a dropper bottle for precise and controlled administration, ensuring targeted treatment for a variety of hair loss and scalp conditions.
Minoxidil, a potent vasodilator, works by increasing blood flow to the scalp, thereby stimulating hair growth. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on dermal papillary cells (DPCs). Minoxidil, the second active ingredient, is a well-known vasodilator that has been proven to stimulate hair growth and slow balding. It functions by widening blood vessels and opening potassium channels, which allows more oxygen, blood, and nutrients to the follicle. This results in a revitalisation of shrunken hair follicles, increasing their size, and prolonging the growth phase of the hair cycle.
Melatonin, a powerful antioxidant, protects the scalp from oxidative damage that can lead to hair loss, aids in reducing inflammation, blocks dihydratestosterone (DHT) and aids in promoting healthy skin cells on the scalp.
Tretinoin, a derivative of vitamin A, is included at a 0.05% concentration. It promotes skin cell turnover and can help improve the skin's texture and tone. In the context of hair loss, tretinoin is believed to enhance the penetration of minoxidil, increasing its effectiveness. Supercharges Minoxidil to promote denser hair regrowth.
17-alpha Estradiol inhibits the conversion of testosterone to the metabolite dihydrotestosterone (DHT) by suppressing 5AR activity. In addition, by inhibiting dehydrogenase, it reduces the conversion process of androstenedione to testosterone, resulting in a reduction in the synthesis of testosterone and DHT.
How Does It Work
Minoxidil is a well-known vasodilator that is commonly used to treat hair loss. It works by widening blood vessels and opening potassium channels, which allows more oxygen, blood, and nutrients to reach the hair follicles. This action can stimulate hair growth and extend the growth phase of the hair cycle.
Tretinoin, a derivative of vitamin A, is included at a 0.01% concentration. It promotes skin cell turnover and can help improve the skin's texture and tone. In the context of hair loss, tretinoin is believed to enhance the penetration of minoxidil, increasing its effectiveness.
Melatonin, a powerful antioxidant, protects the scalp from oxidative damage that can lead to hair loss, aids in reducing inflammation, blocks dihydratestosterone (DHT) and aids in promoting healthy skin cells on the scalp.
17-alpha Estradiol inhibits the conversion of testosterone to the metabolite dihydrotestosterone (DHT) by suppressing 5AR activity. In addition, by inhibiting dehydrogenase, it reduces the conversion process of androstenedione to testosterone, resulting in a reduction in the synthesis of testosterone and DHT.
Possible Side Effects
Like all medicines, your Personalised Scalp Application can cause side effects, although not everybody gets them.
Personalised Scalp Applications may cause the following side effects of unknown frequency (frequency cannot be estimated from the available data):
• Skin irritation may occur. If this happens stop using the product.
• Unwanted non-scalp hair has occasionally been reported. Always wash your hands thoroughly after application and if you accidentally apply the solution to parts of the body other than the scalp, rinse thoroughly with plenty of water.
• Scalp irritation such as local redness, itchiness, dryness, flaky skin have all been reported. This may be due to propylene glycol in the product. This is usually only a temporary effect, but if it is persistent, you should stop using this product.
• Temporary hair loss may occur during the first 2 – 6 weeks of use. This is likely to be because of a change within the growth cycle and it should stop within a couple of weeks. If this hair loss continues for longer than 2 weeks, stop using the product and talk to your prescribing pharmacist.
• Change in hair colour and / or texture may occur.
Please be aware that this treatment may take up to 4-6 months of regular use to show noticeable results.
When Will I See Results?
It usually takes months or years for you to lose hair, so it can take several weeks to GrowBack. 80% of our patients see results within 3-4 months. In the rare instance, that the results are not as desirable as you want, we can increase the strength or add other active ingredients based on your hair health profile. The best results will come from continued use of your recommended treatments and are seen after 4-6 months. You will need to maintain the treatment for continual growth and reduced hair shedding.
How To Use
This formulation can be used by both men and women. Avoid if pregnant or breast feeding. If you are on any medication, please check with our clinical prescriber before using this formulation.
Always perform a patch test before applying to the whole scalp. Apply a small amount of the scalp serum on your scalp and leave on for a few hours. Monitor and observe to check for any irritation, redness, itching or blistering. If there is of these reactions please contact us immediately. If no reactions have been observed then proceed to apply the scalp serum to the areas of treatment. On the first application only use half the dosage amount and leave overnight. If you haven't had any reactions then continue your treatment at full optimal dosing as instructed.
To apply a solution medication, we recommend the following steps:
1. Part your hair down the middle of your head. Then, use a dropper to apply the medication along the part, from the front of your scalp to the back. Make sure you continuously, but gently squeeze out small amounts of the medication as you work your way along the part with the dropper.
2. Part your hair a second and third time to the right and left of your middle part, about 2 inches down. Continuously apply the medication along each part from the front of your scalp to the back.
3. Part your hair a fourth and fifth time just above your right and left ears. Continuously apply the medication along each part from the front of your scalp to the back.
Safety Information
Talk to your prescriber:
• If you suffer from heart disease, including abnormal heart rhythms or rates, angina, or chest pains and / or circulation disorders.
• If you are at all unsure whether your scalp is normal and healthy.
• If you, or a close relative, are suffering or has suffered cancer.
• If you have had any allergic reactions to any applications.
• If you are pregnant, breast feeding or are planning a family.
• If you are unsure of why you have been prescribed this formula.
Take special care when using this product:
• Keep the product away from your eyes and mouth.
• Wash your hands straight after application.
• Before first use, perform a patch test as explained in initial consultation.
• Store product as per dispensing label instructions.
• Use pipette to measure doses. One dose is equivalent to 1ml.
• Do not exceed 2ml within 24 hours.
Driving and using machinery
Using this product is not known to affect your ability to drive or use machinery.
Continued use of application
• You may need to use this medicine daily for at least 4 months before you see new hair growth, this is because hair growth is a slow process.
• Hair growth may be soft and downy at the start but should eventually become the same as normal hair.
• Once the hair has begun to re-grow, you need to continue using this medicine daily for the growth to continue.
• When you stop using the medicine, the hair that has re-grown may disappear after 3-4 months and the balding / hair loss process will continue.
• If you have no improvement in your hair growth after one year of use, you should discontinue treatment.
• Your prescribing pharmacist will guide you each month and will monitor your hair growth progress.
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