
Hair loss treatments have long been dominated by oral finasteride and topical minoxidil, both of which have strong evidence backing their efficacy. However, recent media coverage—particularly the BBC’s report on potential side effects of finasteride—has led to increasing concern among men and women seeking hair loss solutions.
Dr Greg Williams, from the British Association of Hair Restoration Surgery (BAHRS), acknowledged in his BBC interview:"There are some men who will experience side effects, and there are some men who feel very strongly about the potential risk. The important thing is informed consent and ensuring patients understand the balance of benefits and risks before starting treatment."
For those who cannot take finasteride due to contraindications or concerns about side effects, a finasteride-free topical DHT blocker offers a viable alternative. Our formula combines Saw Palmetto, Melatonin, and Arginine—a synergistic trio that blocks DHT, improves scalp circulation, and promotes hair quality without systemic hormonal interference.
It is important to note that no treatment is completely side-effect free, and a consultation is required before initiating this topical solution to ensure suitability.
Understanding DHT and Hair Loss
Dihydrotestosterone (DHT) is a byproduct of testosterone, formed when the enzyme 5-alpha reductase converts testosterone into DHT. In genetically susceptible individuals, DHT shrinks hair follicles, leading to shortened growth cycles, weaker strands, and eventually progressive hair thinning.
Finasteride works by inhibiting the 5-alpha reductase enzyme, thereby reducing DHT levels. However, concerns about its potential side effects, including sexual dysfunction and mood changes, have led many to seek non-hormonal alternatives.
Our topical DHT blocker provides a natural yet effective substitute, targeting hair loss through multiple pathways without altering systemic hormone levels.
Key Ingredients & Their Synergistic Benefits
1. Saw Palmetto – A Natural 5-Alpha Reductase Inhibitor
Saw Palmetto (Serenoa repens) is a plant extract known for its DHT-blocking properties. Several studies suggest that it inhibits the 5-alpha reductase enzyme, reducing DHT production at the scalp level.
Why it’s a good alternative to finasteride:
Blocks DHT activity without systemic hormonal impact
Shown in clinical studies to reduce hair shedding and improve hair density
Does not interfere with testosterone levels, making it a safer choice for individuals sensitive to hormonal treatments
A 2020 study published in the International Journal of Trichology found that topical saw palmetto formulations improved hair density and reduced shedding in men with androgenetic alopecia (AGA), with no significant side effects reported.
2. Melatonin – An Anti-Oxidant and Growth Stimulant
Melatonin is best known for its role in regulating sleep, but research has uncovered its potent benefits for hair growth.
Mechanisms of action:
Antioxidant Properties:Â Protects follicles from oxidative stress, which contributes to hair thinning.
DHT Reduction: Melatonin has been shown to reduce androgen receptor activity, limiting DHT’s impact on hair follicles.
Hair Cycle Regulation:Â Melatonin prolongs the anagen (growth) phase, improving hair thickness and density.
A study published in International Journal of Molecular Sciences (2019)Â found that topical melatonin increased hair density in both men and women with AGA, making it an ideal ingredient for supporting follicular function.
3. Arginine – A Circulation Booster for Stronger Follicles
Arginine is a precursor to nitric oxide (NO), which plays a key role in vasodilation—the widening of blood vessels.
Why this matters for hair loss:
Improved Scalp Circulation: Increases oxygen and nutrient delivery to follicles, promoting healthier hair growth.
Reduces Follicle Miniaturisation:Â Enhances follicular function and delays DHT-induced shrinkage.
Strengthens Hair Fibres:Â Arginine is an amino acid that fortifies the hair shaft, reducing breakage and improving overall hair quality.
Clinical research suggests that topical arginine formulations improve hair density and thickness by enhancing follicle resilience.
Why This Combination Works Best
The Saw Palmetto + Melatonin + Arginine formulation provides a multi-targeted approach to treating hair loss:
✅ DHT Reduction – Saw Palmetto blocks DHT at the follicle level.
✅ Improved Circulation – Arginine increases blood flow, ensuring optimal nutrient delivery.
✅ Follicle Protection – Melatonin’s antioxidant effects shield hair follicles from oxidative damage.
✅ Hair Cycle Support – Melatonin prolongs the growth phase, while Arginine delays follicular miniaturisation.
Unlike finasteride, which works only through DHT suppression, this finasteride-free formula targets multiple factors involved in hair thinning, making it a powerful non-hormonal alternative.
What to Expect & Treatment Timeline
Hair loss treatments take time—this topical solution must be used consistently for at least 4-6 months before visible improvements are seen.
Individual results vary depending on genetics, scalp health, and adherence to treatment.
Can be used as a stand-alone treatment or alongside other therapies such as minoxidil or microneedling for enhanced results.
As with all treatments, a consultation is required before starting to assess suitability and ensure the best treatment plan is in place.
Final Thoughts
With growing concerns around the side effects of oral finasteride, topical DHT blockers provide a safer, non-hormonal alternative for those who cannot or do not wish to use finasteride.
Our formulation—combining Saw Palmetto, Melatonin, and Arginine—is a clinically-backed, multi-targeted approach to treating hair loss, improving scalp health, supporting stronger follicles, and reducing the effects of DHT without systemic interference.
Hair loss is a journey, and no solution is instant. However, with commitment, consistency, and the right formulation, it is possible to slow hair loss and support healthy regrowth.
References
Trüeb RM, et al. Melatonin protects hair follicles against oxidative stress-induced premature catagen development. Int J Mol Sci. 2019.
Winiwarter H, et al. Serenoa repens extract in the treatment of androgenetic alopecia: A review. Int J Trichol. 2020.
Koch EL, et al. Arginine-derived nitric oxide in scalp circulation and hair follicle vitality. J Dermatol Sci. 2018.
BBC News. Finasteride and hair loss: The concerns over potential side effects. 2024.
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